Efficacy of ambruticin analogs in a murine model of invasive pulmonary aspergillosis.

نویسندگان

  • Lisa Y Chiang
  • Daniele E Ejzykowicz
  • Zong-Qiang Tian
  • Leonard Katz
  • Scott G Filler
چکیده

Ambruticins are a family of polyketides. The antifungal activity of an ambruticin, KOSN-2079, was tested in the mouse model of invasive aspergillosis. KOSN-2079 significantly reduced pulmonary fungal burdens and improved survival over that with the vehicle control. These results support the continued development of ambruticins as antifungal agents.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 50 10  شماره 

صفحات  -

تاریخ انتشار 2006